5-lipoxygenase Antibody

Arachidonate 5-lipoxygenase (ALOX5) catalyzes the first step in leukotriene biosynthesis and plays a role in inflammatory processes. 5-lipoxygenase is expressed specifically in bone marrow-derived cells. This enzyme catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(s)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma. These mutations are also associated with atherosclerosis and several cancers.