Rabbit Polyclonal Antibody
ATP-binding cassette sub-family B member 6, mitochondrial (ABCB6) binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. ABCB6 plays a crucial role in heme synthesis. Depletion of ABCB6 by RNAi abrogates heme biosynthesis. Overexpression enhances porphyrin biosynthesis.