Rabbit Polyclonal Antibody
ATP-binding cassette sub-family G member 8 (ABCG8) is a transporter that plays an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Genetic variations in ABCG8 can be associated with susceptibility to gallbladder disease type 4 (GBD4). Defects in ABCG8 are also a cause of sitosterolemia (SITOST), also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile.