AR Antibody

Catalog Number

250548

Unit

0.1 mg

Price

$231.00

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Description

The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors, which regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. AR consists of an amino terminal modulating domain, a central DNA-binding domain, a hinge region and a carboxyl terminal ligand binding domain. Defects in AR are the cause of androgen insensibility syndrome (genital disorders), X-linked spinal and bulbar muscular atrophy (Kennedy disease), metastatic prostate cancer, and infertility male syndrome.

Alternate Names

Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; AR; DHTR; NR3C4

Accession No.

P10275

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human AR.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.