Leptin Receptor (long) Antibody

Rabbit Polyclonal

Catalog Number

250739

Unit

0.1 mg

Price

$231.00

Isotype

Rabbit Ig

Applications

E, WB, IHC

Species reactivity

H, M, R

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Cat. No. 250739: The Leptin Receptor (long) is used in Western blot to detect the leptin receptor in mouse brain lysate.Cat. No. 250739: The Leptin Receptor (long) Antibody is used in Western blot to detect the leptin receptor in mouse brain lysate.Leptin receptor (long) staining in rabbit articular cartilage: Paraffin-embedded rabbit articular cartilage is stained with Leptin receptor (long) Antibody (Cat. No. 250739) used at 1:200 dilution.Leptin receptor (long) staining in rabbit articular cartilage: Paraffin-embedded rabbit articular cartilage is stained with Leptin receptor (long) Antibody (Cat. No. 250739) used at 1:200 dilution.

Description

The Leptin receptor (OB receptor, OBR) is the receptor for the obesity factor (leptin). The Leptin Receptor is involved in the regulation of fat metabolism and in lymphopoiesis. The Leptin receptor is closely related to the gp130 signal transducing component common to the IL-6, LIF, CNTF and G-CSF receptors. The Leptin receptor has multiple isoforms (A-E) with isoform B (OBRb) being the long single-pass type I membrane receptor, isoform C (OBRa) carrying a short cytoplasmic domain, and isoform E a shorter secreted form. This antibody is specific for the long form (isoform B).


Product Citations

Connor K et al. Journal of Developmental Origins of Health and Disease. 2010. doi:10.1017/S2040174410000346.

Alternate Names

Leptin receptor; LEP-R; OB receptor; OB-R; HuB219; CD295 antigen; LEPR; DB; OBR

Accession No.

P48357

Antigen

KLH-conjugated synthetic peptide encompassing a sequence unique to isoform B (long form) of human Leptin Receptor.

Application Notes

E: 1:500-1:1,000

WB: 1:100-1:500

IHC: 1:200-1:500

 

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Cellular Antigens,  Receptors & Channels,  Endocrine System, Signal Transduction, Signaling Molecules & Interaction

For research use only, not for diagnostic or therapeutic procedures.