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Pan-Cadherin Antibody

Mouse Monoclonal Antibody
Cat. No. 
251786
Unit 
0.1 mg
Price $292.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 

Cadherins are calcium dependent cell adhesion proteins. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins contribute to the sorting of heterogeneous cell types. N-cadherin functions during gastrulation and is required for establishment of left-right asymmetry. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway which phosphorylates beta-catenins attached to both N-cadherin and E-cadherins.