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PYK2 (5E2D) Antibody

Mouse Monoclonal Antibody
Cat. No. 
252776
Unit 
0.1 ml
Price $388.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
PYK2 (PTK2B protein tyrosine kinase 2 beta) is a cytoplasmic protein tyrosine kinase. It is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PYK2 may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK and the SH2 domain of GRB2. This protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.