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Tau Protein Antibody

Rabbit Polyclonal Antibody
Cat. No. 
250873
Unit 
0.1 mg
Price $277.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 

Tau protein promotes microtubule assembly and stability. Tau is also involved in the establishment and maintenance of neural polarity. The C-terminus domain of Tau binds to axonal microtubules whereas the N-terminus domain binds to neural plasma membrane components, therefore suggesting that Tau protein functions as a linker between the two. Axonal polarity is predetermined by tau localization in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. PNS-tau is expressed in the peripheral nervous system whereas the other isoforms are expressed in the central nervous system. Defects in Tau protein are a cause of dementia, parkinsonism and Alzheimer disease.