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Tryptophan Hydroxylase (Ser260) Antibody

Rabbit Polyclonal Antibody
Phosphospecific Antibody
Cat. No. 
252590
Unit 
0.1 ml
Price $385.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
Tryptophan 5-hydroxylase 1 (TPH) catalyzes the following reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin. TPH belongs to the biopterin-dependent aromatic amino acid hydroxylase family. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II). CaM K II phosphorylates Ser260 which lies within the regulatory domain of TPH.