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Wee1 Antibody

Rabbit Polyclonal Antibody
Cat. No. 
252157
Unit 
0.1 mg
Price $330.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
Wee1 acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. The activity of wee1 increases during the S and G2 phases, and decreases in M phase when it is hyperphosphorylated. A correlated decrease in wee1 protein level occurs at M/G1 phase, probably due to its degradation. Wee1 specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. The phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur.