Modification Specific Antibody

DNA transcription cannot take place unless DNA is unwound from the nucleosomes. The cell unwinds DNA by acetylation of lysine residues of histones. Research has shown that acetylation of non-histone proteins (e.g. transcription factors) and histones are involved in transcription. This pan-specific antibody recognizes proteins with acetyllysine residues. This antibody has been utilized for proteomic studies of protein acetylation, immunoaffinity chromatography separation and isolation of acetylated proteins and peptides from protease-digested whole cells.