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Endothelin 1 Peptide

Synthetic Peptide
Cat. No. 
350161
Unit 
1 mg
Price $725.00

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Abbiotec

7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 

Endothelin-1 (ET-1) is the predominant isoform of the endothelins, a family of endothelium-derived vasoconstrictor peptides. Endothelin-1 is expressed as a 212-aa precursor (preproendothelin-1) that is sequentially cleaved into 2 chains: Endothelin-1 (21 aa) and Big Endothelin-1 (38 aa). Big endothelin-1 is cleaved to yield endothelin-1 via the activity of an endothelin-converting enzyme (ECE), chymases and non-ECE metalloproteases. ET-1 exerts various biological effects, including vasoconstriction and the stimulation of cell proliferation in tissues via ET receptors A and B.