VIP Peptide (Guinea Pig)
VIP peptides cause vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach, and gall bladder. The vasoactive intestinal peptide (VIP) is a 28-aa long peptide corresponding to aa45-72 of the guinea pig VIP precursor after cleavage. VIP is a neuropeptide synthesized in the central nervous system, which enhances the formation of adenosine 3'-5'-cyclic monophosphate in cerebral cortex and hypothalamus. VIP also modulates the cholinergic as well as serotonergic neurotransmitter systems.