Type II collagen (COL2A1) is specific for cartilaginous tissues. Type II collagen is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Defects in COL2A1 are the cause of a variety of chondrodysplasia including hypochondrogenesis and osteoarthritis.
CD4 antigen is found on a T-cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. CD4 is also present on 80% of thymocytes and at a lower level on monocytes. CD4 is involved in recognition of antigen presented along with MHC class II by APCs. CD4 is the primary cellular receptor for the human immunodeficiency virus (HIV).
The RGES peptide is a RGD-related peptide.
The RGD peptide is the binding motif of fibronectin to cell adhesion molecules.