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Cytoskeleton Proteins

Annexin II Antibody

$280.00
SKU: 252069
Annexins are a multigene family of Ca++-regulated phospholipid-binding proteins. They serve as membrane-membrane, or membrane-cytoskeleton linkers, and regulate the formation of lipid domains in the plasma membrane. Annexins possess a series of unique 70 amino acid annexin-repeat modules that form a curved disk and allow for the creation of an intercessory complex between plasma membrane and cytofilaments. Annexin II is a heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Annexin II interacts with ATP1B1 and DYSF.
List price: $0.00
Price: $280.00

Calponin-3 Antibody

$245.00
SKU: 251988
Calponin-3 is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. Calponin-3 is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin-3 with actin inhibits actomyosin Mg-ATPase activity.
List price: $0.00
Price: $245.00

Gamma-actin Antibody

$245.00
SKU: 251971
Actin, cytoplasmic 2 (gamma-actin) is a highly conserved protein that is involved in various types of cell motility processes, and is ubiquitously expressed in all eukaryotic cells. Defects in gamma-actin are the cause of deafness autosomal dominant type 20, also called autosomal dominant deafness type 26 (DFNA26). DFNA20 is a form of sensorineural hearing loss.
List price: $0.00
Price: $245.00

Cytokeratin-1 Antibody

$245.00
SKU: 251612
Cytokeratin-1 regulates the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). Defects in KRT1 are a cause of bullous congenital ichthyosiform erythroderma, also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persists into adulthood
List price: $0.00
Price: $245.00

APC Peptide

$50.00
SKU: 350494
The adenomatous polyposis coli protein (APC) is a tumor suppressor that promotes rapid degradation of catenin-beta 1 (CTNNB1) and participates in Wnt signaling. The GSK3-beta protein kinase regulates its activity by phosphorylation. APC binds to PDZ domains of DLG1 and 3, to catenins, axin and MAPRE protein family including the EB members.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Cytoskeleton Proteins
Pathway and Disease 
Signal Transduction
Cell Motility
Cancers
Format 
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Adenomatous polyposis coli protein; protein APC; DP2.5
Composition 
C79H136N28O28S2
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200132 is selected from a sequence within the N-term region of human APC. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1990.2 g/mol
Unit 
0.1 mg
Accession No.  
P25054

OCM2 293 Cell Lysate

$392.00
SKU: 407853
Antigen standard for oncomodulin 2 (OCM2) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid (True ORF cDNA clone RC224075, OriGene Technologies, Inc.) and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
List price: $0.00
Image 
OCM2 lysate validation: The OCM2 293 Cell Lysate (lane B) and Control Vector Cell Lysate (lane A) are used in Western blot to detect tagged-OCM2 with a DDK Antibody.
Subcategory 
Cell Lysate
Price: $392.00
Protein Family 
Cytoskeleton Proteins
Pathway and Disease 
Signaling Molecules and Interaction
ORF Clone URL 
http://www.origene.com/orf_clone/search/retrieve_results.mspx?accn=NM_006188&sku...
Format 
This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Applications 
ELISA
WB
IP
Alternate Names 
oncomodulin-like; oncomodulin-2; oncomodulin; OM; parvalbumin beta; OCM2; OCM; oncomodulin-1; OCM1; OCMN
Application Notes 
WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Storage 
Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Release Date 
Thursday, December 13, 2012
Unit 
0.1 mg
Accession No.  
NP_006179

STOML2 293 Cell Lysate

$392.00
SKU: 407324
Antigen standard for stomatin (EPB72)-like 2 (STOML2) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid (True ORF cDNA clone RC204046, OriGene Technologies, Inc.) and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
List price: $0.00
Image 
STOML2 lysate validation: The STOML2 293 Cell Lysate (lane B) and Control Vector Cell Lysate (lane A) are used in Western blot to detect tagged-STOML2 with a DDK Antibody.
Subcategory 
Cell Lysate
Price: $392.00
Protein Family 
Cytoskeleton Proteins
Pathway and Disease 
Signaling Molecules and Interaction
ORF Clone URL 
http://www.origene.com/orf_clone/trueclone/accession/NM_013442/RC204046.aspx
Format 
This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Applications 
ELISA
WB
IP
Alternate Names 
stomatin-like protein 2; stomatin-like 2; EPB72-like protein 2; STOML2; HSPC108; SLP-2
Application Notes 
WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Storage 
Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Release Date 
Thursday, December 13, 2012
Unit 
0.1 mg
Accession No.  
NP_038470

CKIP1 Antibody

$265.00
SKU: 254154

CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha’, and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton.

List price: $0.00
Price: $265.00

Vimentin Antibody

$280.00
SKU: 253238
Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. Vimentin is involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin is also implicated in steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Immunohistochemical staining for vimentin is characteristic of sarcomas (or neural, muscle and fibroblast origin) as compared to carcinomas which are generally negative.
List price: $0.00
Price: $280.00

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