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Enzymes

MDM2 Antibody

$265.00
SKU: 254518

MDM2 mediates ubiquitination of p53/TP53, leading to its degration by the proteasome. MDM2 inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding to their respective transcriptional activation domains. MDM2 also acts as an ubiquitin ligase towards itself and ARRB1, permits the nuclear export of TP53/p53, and promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.

The MDM2 Antibody (Cat. No. 254518) is used in Western blot to detect MDM2 in mouse liver tissue.
List price: $0.00
Price: $265.00

Trypsin Substrate Peptide

$645.00
SKU: 350577

This peptide is a fluorogenic substrate for trypsin, a peptidase S1 family members that cleaves at Arg-Xaa and Lys-Xaa sites within proteins. The peptide is labeled with rhodamine 110, a highly fluororescent dye upon substrate cleavage (Abs/Em = 497/520 nm).

List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Price: $645.00
Protein Family 
Enzymes
Peptidases
Pathway and Disease 
Signaling Molecules and Interaction
Format 
Each vial contains 5 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
Alternate Names 
Trypsin-1; Trypsin I; Cationic trypsinogen; Serine protease 1; PRSS1; TRP1; TRY1; TRYP1
Composition 
C54H62Cl2N12O11
Sequence 
(Z-Ala-Arg)2-R110
Purity 
Purity > 95% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Wednesday, March 27, 2013
Subcategory 
Substrate Peptide
Synthetic Peptide
MW 
1126.0 g/mol
Unit 
5 mg
Accession No.  
P07477

BTK Antibody

$265.00
SKU: 254516

BTK (Tyrosine-protein kinase BTK) is a tyrosine kinase that plays a crucial role in B-cell ontogeny. Defects in BTK are the cause of X-linked agammaglobulinemia (XLA) also known as X-linked agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD1). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes.

List price: $0.00
Price: $265.00

JNK1 Antibody

$280.00
SKU: 252187
c-Jun N-terminal kinase 1 (JNK1) responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2. This regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK1 phosphorylates heat shock factor protein 4 (HSF4).
List price: $0.00
Price: $280.00

ADAM 19 Antibody

$280.00
SKU: 251997
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell development. ADAM19 also cleaves alpha-2 macroglobulin and is involved in osteoblast differentiation and/or osteoblast activity in bone.
List price: $0.00
Price: $280.00

RBBP6 Antibody

$245.00
SKU: 251916
E3 ubiquitin-protein ligase RBBP6 (RBBP6) is an E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. RBBP6 plays a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in the increase of MDM2-mediated ubiquitination and degradation of p53/TP53. RBBP6 functions as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
List price: $0.00
Price: $245.00

Caspase-1 Antibody

$280.00
SKU: 251903
Caspase-1 is a thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Caspase-1 important for defense against pathogens. Caspase-1 cleaves and activates sterol regulatory element binding proteins (SREBPs), and also promotes apoptosis. Caspase-1 is specifically inhibited by the cowpox virus Crma protein
List price: $0.00
Price: $280.00

NADPH Oxidase 4 Antibody

$245.00
SKU: 251462
NOX4 (NADPH oxidase 4) generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. NOX4 regulates signaling cascades probably through phosphatase inhibition. NOX4 functions as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. NOX4 produces superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation.
List price: $0.00
Price: $245.00

TrkC Antibody

$231.00
SKU: 250897
The Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B gp 145.
List price: $0.00
Price: $231.00

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