Protein Kinases

Pathway and Disease

Glycan Biosynthesis and Metabolism

Nervous and Sensory Systems

Signal Transduction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

Substrate: Glycogen synthase; GYS1; GYS; Enzyme: Calcium/calmodulin-dependent protein kinase type II alpha chain; CaM-kinase II alpha chain; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2A; CAMKA; KIAA0968

Composition

C44H80N18O15

Sequence

Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ser-Ser-NH2 or PLSRTLSVSS-NH2

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Substrate Peptide

MW

1045.1 g/mol

Unit

1 mg

Accession No.

P13834

Q9UQM7

cGKI Kinase Inhibitor Peptide

$69.00

SKU: 350001

The peptide is a synthetic inhibitor of the cGKI protein kinase. The sequence corresponds to the mutated S32A phosphorylation site analog within residues 29-35 of human histone H2B. The cGKI kinase belongs to the AGC Ser/Thr family, cGMP subfamily, and has two isoforms, alpha and beta, that become active upon homodimerization and cGMP binding.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Price: $69.00

Protein Family

Pathway and Disease

Signal Transduction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

Substrate: Histone H2B; Inhibitor: cGMP-dependent protein kinase 1; CGK 1; cGKI; PRKG1; PRKGR1

Composition

C38H74N18O10

Sequence

Arg-Lys-Arg-Ala-Arg-Lys-Glu or RKRARKE

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Inhibitory Peptide

MW

943.2 g/mol

Unit

1 mg

Accession No.

P33778

Q13976

WNK4 Peptide

$80.00

SKU: 350572

Ser/Thr-protein kinase WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation, which prevents membrane trafficking of SLC12A3. WNK4 also inhibits the renal potassium channel KCNJ1 via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 acts as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. WNK4 is exclusively present in intercellular junctions in th edistal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. Defects in WNK4 are a cause of pseudohypoaldosteronism type II (PHAII).

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Pathway and Disease

Membrane Transport

Metabolic Disorders

Signaling Molecules and Interaction

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

WNK4; Ser/Thr-protein kinase WNK4; Serine/threonine-protein kinase WNK4; protein kinase with no lysine 4; protein kinase, lysine–deficient 4

Composition

C64H89N13O21

Sequence

The synthetic peptide used to raise the antibody Cat. No. 250912 is selected from a sequence within the N-term region of mouse WNK4. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Blocking Peptide

MW

1375.6 g/mol

Unit

0.1 mg

Accession No.

Q96J92

Opioid Receptor Antagonist Peptide

$83.00

SKU: 350306

This is an antagonist of opoid receptors

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Price: $83.00

Protein Family

Receptors and Channels

Pathway and Disease

Metabolic Disorders

cell communication

Endocrine System

Membrane Transport

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

NONE

Composition

C44H66N12O7S2

Sequence

Ac-Arg-Phe-Met-Trp-Met-Lys-NH2 or Ac-RFMWMK-NH2

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

939.2 g/mol

Unit

1 mg

Accession No.

HER2/neu [654-662] Peptide

$80.00

SKU: 350219

HER2/neu is an essiential part of a Neuregulin-receptor complex. It contains a tyrosine phosphatase activity and has GP30 as a possible ligand.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Price: $80.00

Protein Family

Receptors and Channels

Pathway and Disease

Cancers

Cell Communication

Development and Behavior

Signal Transduction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

Receptor tyrosine-protein kinase erbB-2; EC2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine Kinase-type cell surface receptor HER2; MLN 19; CD340 antigen; ERBB2; HER2; NEU; NGL

Composition

C42H77N9O11

Sequence

Human: H-Ile-Ile-Ser-Ala-Val-Val-Gly-Ile-Leu-OH or H-IISAVVGIL-OH

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

884.12 g/mol

Unit

1 mg

Accession No.

P04626

CaMK2a Peptide

$80.00

SKU: 300117

CaMK2a (CAMKII alpha, CaM Kinase 2 alpha) is a prominent Ser/Thr kinase in the central nervous system thatfunctions in long-term potentiation and neurotransmitter release. A member of the NMDAR signaling complex at the excitatory synapse, it regulates NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. CAMK2a is composed of alpha, beta, gamma, and delta chains that assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. CaMK2a interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

Price: $80.00

Protein Family

Pathway and Disease

Development and Behavior

Nervous and Sensory Systems

Signal Transduction

Format

Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.

Alternate Names

CaMK2a; Calcium/calmodulin-dependent protein kinase type II alpha chain; CaM-kinase II alpha chain; CaM kinase II subunit alpha; CaMK-II subunit alpha

Sequence

The synthetic peptide used to raise the antibody Cat. No. 250569 is selected from a sequence within the C-term region of human CaMK2a. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.

Purity

Purity > 80% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Blocking Peptide

MW

11400 g/mol (MAP8 peptide)

Unit

0.1 mg

Accession No.

Q9UQM7

2B-(S) Peptide

$90.00

SKU: 350454

Specific substrate for phosphorylation assays

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Price: $90.00

Protein Family

Pathway and Disease

Signal Trasduction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

NONE

Composition

C81H138N28O29S

Sequence

Biotin-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-Ser-Pro-Gln-Leu-OH or Biotin-RRAAEELDSRAGSPQL-OH

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

2000.24 g/mol

Unit

1 mg

Accession No.

2B-(A) Peptide

$90.00

SKU: 350453

Specific substrate for phosphorylation assays

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Price: $90.00

Protein Family

Pathway and Disease

Signal Trasduction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

NONE

Composition

C81H137N28O28S

Sequence

Biotin-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-Ala-Pro-Gln-Leu-OH or Biotin-RRAAEELDSRAGAPQL-OH

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

MW

1983.23 g/mol

Unit

1 mg

Accession No.

Tyrosine Protein Kinase Substrate Peptide

$89.00

SKU: 350010

This peptide is a substrate for tyrosine protein kinases such as EGFR and Src subfamily members. The sequence derives from the residues 412-422 of the Tyr-419 tyrosine autophosphorylation site of the proto-oncogene tyrosine protien kinase Src (c-Src).

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Price: $89.00

Protein Family

Pathway and Disease

Cell Communication

Infectious Diseases

Signal Transduction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

Proto-oncogene tyrosine-protein kinase Src; p60-Src; c-Src; pp60c-src; SRC; SRC1

Composition

C66H109N23O23

Sequence

Arg-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Gly or RRLIEDNEYTARG

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Substrate Peptide

MW

1592.9 g/mol

Unit

1 mg

Accession No.

P12931

Autocamtide-2 Peptide

$89.00

SKU: 350003

Autocamtide-2 is a highly selective peptide substrate for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence derives from the Thr-286 autophosphorylation site of the alpha subunit of CaMKII. Autocamtide-2 contains the R-X-X-S/T consensus site surrounded by basic residues for improved binding to phosphocellulose. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CaMKII phosphorylates Autocamtide-2 with a Km of 2 uM whereas protein kinase C (PKC) has a Km > 50 uM and protein kinase A (PKA) has no activity.

List price: $0.00

Storage

Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.

Price: $89.00

Protein Family

Pathway and Disease

Nervous and Sensory Systems

Signal Transduction

Format

Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

Alternate Names

Calcium/calmodulin-dependent protein kinase type II alpha chain; CaM-kinase II alpha chain; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2A; CAMKA; KIAA0968

Composition

C65H118N22O20

Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu or KKALRRQETVDAL

Purity

Purity > 95% by HPLC

Solubility

Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Release Date

Monday, December 17, 2012

Subcategory

Substrate Peptide