Proteoglycans

Tetranectin (TN) is a serum and tissue protein, a C-type lectin, which binds to Ca++. It is a homotrimer of monomers each with a mass of 20 kDa, plasma or serum concentrations of TN are found to be approximately 10 mg/l. In vitro, TN can bind to kringle 4 of plasminogen and enhance the activation of plaminogen to plasmin, catalyzed by tissue plasminogen activator in the presence of poly-D-lysine. TN is best known as a prognostic marker in ovarian cancer. This antibody is specific for amino acids 17-181 of human tetranectin monomer.

Perlecan is an extracellular matrix proteoglycan. It has a large core protein of 400-450 kDa and is often produced with heparan sulfate side chains. Perlecan is found in basement membranes where it contributes to the permeability characteristics, serves as a substrate for vascular cells and binds growth factors involved in vascular remodelling. This antibody is highly specific for perlecan. There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, fibronectin, elastin, collagen, laminin This antibody reacts with human perlecan.

Perlecan is an extracellular matrix proteoglycan. It has a large core protein of 400-450 kDa and is often produced with heparan sulfate side chains. Perlecan is found in basement membranes where it contributes to the permeability characteristics, serves as a substrate for vascular cells and binds growth factors involved in vascular remodelling. This antibody is highly specific for perlecan. There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, fibronectin, elastin, collagen, laminin This antibody reacts with human perlecan.

Endostatin is a 20 kDa C-terminal peptide fragment derived from collagen XVIII. Endostatin is an angiogenesis inhibitor that can cause nearly complete suppression of tumor-induced angiogenesis and strong antitumor activity by preventing the endothelial cells to migrate. Endostatin competes with fibronectin at RGD binding sites on the receptor alpha-5 beta-1 integrin. This antibody recognizes human endostatin in ELISA.

Amyloid beta A4 protein (beta-amyloid protein) functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Beta-amyloid protein is involved in cell mobility and transcription regulation through protein-protein interactions. Beta-amyloid protein promotes transcriptional activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1). AD1 is a familial early-onset form of Alzheimer disease.