Glypican-3 (GPC3) is a cell surface proteoglycan that bears heparan sulfate. GPC3 is likely involved in the modulation of growth in the predominantly mesodermal tissues and organs. Defects in GPC3 are the cause of pre- and postnatal overgrowth (gigantism, Simpson-Golabi-Behmel syndrome).
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Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Pathway and Disease
Development and Behavior
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Intestinal protein OCI-5; GTR2-2; MXR7; GPC3; OCI5
The synthetic peptide used to raise the antibody Cat. No. 200135 is selected from a sequence within the N-term region of human Glypican-3. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity > 80% by HPLC
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Monday, December 17, 2012