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Ubiquitins

MDM2 Antibody

$265.00
SKU: 254518

MDM2 mediates ubiquitination of p53/TP53, leading to its degration by the proteasome. MDM2 inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding to their respective transcriptional activation domains. MDM2 also acts as an ubiquitin ligase towards itself and ARRB1, permits the nuclear export of TP53/p53, and promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.

The MDM2 Antibody (Cat. No. 254518) is used in Western blot to detect MDM2 in mouse liver tissue.
List price: $0.00
Price: $265.00

RBBP6 Antibody

$245.00
SKU: 251916
E3 ubiquitin-protein ligase RBBP6 (RBBP6) is an E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. RBBP6 plays a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in the increase of MDM2-mediated ubiquitination and degradation of p53/TP53. RBBP6 functions as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
List price: $0.00
Price: $245.00

Bmi1 Peptide

$50.00
SKU: 350547
Polycomb complex protein BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex that maintains the transcriptionally repressive state of many genes, including Hox genes throughout development. PcG PRC1 complex forms Polycomb bodies that act via chromatin remodeling and histone modification. BMI-1 cooperates with Myc oncogene to produce B-lymphomas.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Transcription Factors
Ubiquitins
Pathway and Disease 
Cancers
Folding
Sorting and Degradation
Transcription
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; PCGF4; RNF51
Composition 
C79H128N30O27S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200185 is selected from a sequence within the C-term region of human Bmi1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1962.1 g/mol
Unit 
0.1 mg
Accession No.  
P35226

PML Peptide

$50.00
SKU: 350546
Promyelocytic leukemia protein (PML) is a transcription factor involved in transcriptional regulation and nuclear protein sequestration, such as recruiting ELF4 into PML nuclear bodies. A chromosomal aberration involving PML is a cause of acute promyelocytic leukemia.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Transcription Factors
Ubiquitins
Pathway and Disease 
Cancers
Folding
Sorting and Degradation
Transcription
Format 
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Probable transcription factor PML; Tripartite motif-containing protein 19; RING finger protein 71; PML; MYL; RNF71; TRIM19; Promyelocytic leukemia protein
Composition 
C80H131N29O27S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200184 is selected from a sequence within the N-term region of human PML. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1963.1 g/mol
Unit 
0.1 mg
Accession No.  
P29590

FANCL Peptide

$50.00
SKU: 350524
Fanconi anemia group L protein (FANCL) is an ubiquitin ligase that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. FANCL is required for proper primordial germ cell proliferation in the embryonic stage. Defects in FANCA are the cause of Fanconi anemia, a syndrome characterized by pancytopenia, congenital malformations and predisposition to cancers caused by a hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Ubiquitins
Pathway and Disease 
Cancers
Folding
Sorting and Degradation
Replication and Repair
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
E3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43; FANCL; PHF9
Composition 
C85H135N27O29S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200162 is selected from a sequence within the N-term region of human FANCL. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2031.2 g/mol
Unit 
0.1 mg
Accession No.  
Q9NW38

BRCA1 Peptide

$50.00
SKU: 350522
Breast cancer type 1 susceptibility protein (BRCA1) plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BRCA1 are a cause of genetic susceptibility to breast and ovarian cancers.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Transcription Factors
Ubiquitins
Pathway and Disease 
Cancers
Cell Growth and Death
Folding
Sorting and Degradation
Replication and Repair
Transcription
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Breast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1; RNF53
Composition 
C88H149N29O31S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200160 is selected from a sequence within the N-term region of human BRCA1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2141.3 g/mol
Unit 
0.1 mg
Accession No.  
P38398

VHL Peptide

$50.00
SKU: 350504
VHL is involved in the ubiquitination and subsequent proteasomal degradation of hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Defects in VHL are the cause of different types of cancers (pheochromocytoma, von Hippel-Lindau disease) and erythrocytosis.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Ubiquitins
Pathway and Disease 
Cancers
Folding
Sorting and Degradation
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Von Hippel-Lindau disease tumor suppressor; pVHL; G7 protein; VHL
Composition 
C86H133N25O32S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200142 is selected from a sequence within the C-term region of human VHL. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2061.2 g/mol
Unit 
0.1 mg
Accession No.  
P40337

CYLD Peptide

$50.00
SKU: 350498
CYLD is a negative regulator of TRAF2 and NF-kappa B signaling pathway. CYLD has a deubiquitinating activity that is directed towards non-Lys48-linked polyubiquitin chains. Defects in CYLD are the cause of familial cylindromatosis, a highly tumor type-specific disorder.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Enzymes
Peptidases
Ubiquitins
Pathway and Disease 
Cancers
Signaling Molecules and Interaction
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Probable ubiquitin carboxyl-terminal hydrolase CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD; Deubiquitinating enzyme CYLD; CYLD1
Composition 
C97H141N25O31S1
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200136 is selected from a sequence within the N-term region of human CYLD. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2185.4 g/mol
Unit 
0.1 mg
Accession No.  
Q9NQC7

SUMO2/3 Peptide

$50.00
SKU: 350492
SUMO2 and SUMO3 are ubiquitin-like proteins which can be covalently attached to target lysines as a monomer. SUMO proteins play a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Ubiquitins
Pathway and Disease 
Folding
Sorting and Degradation
Format 
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Small ubiquitin-related modifier 2; Ubiquitin-like protein SMT3B; SMT3 homolog 2; Sentrin-2; HSMT3; Small ubiquitin-related modifier 3; Ubiquitin-like protein SMT3A; SMT3 homolog 1; SUMO2; SMT3H2; SUMO3
Composition 
C78H123N19O34S2
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200130 is selected from a sequence within the C-term region of human SUMO2/3. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
1935 g/mol
Unit 
0.1 mg
Accession No.  
P61956
P55854

SUMO1 Peptide

$50.00
SKU: 350491
SUMO1 is an ubiquitin-like protein which can be covalently attached to target lysines as a monomer. SUMO1 plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.
List price: $0.00
Storage 
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Price: $50.00
Protein Family 
Ubiquitins
Pathway and Disease 
Folding
Sorting and Degradation
Format 
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Alternate Names 
Small ubiquitin-related modifier 1; Ubiquitin-like protein SMT3C; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein UBL1; Ubiquitin-related protein SUMO-1; GAP modifying protein 1; GMP1; Sentrin; SMT homolog 3; SUMO1; SMT3H3
Composition 
C84H135N25O33S2
Sequence 
The synthetic peptide used to raise the antibody Cat. No. 200129 is selected from a sequence within the C-term region of human SUMO1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity 
Purity > 80% by HPLC
Solubility 
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Release Date 
Monday, December 17, 2012
Subcategory 
Synthetic Peptide
Blocking Peptide
MW 
2087.2 g/mol
Unit 
0.1 mg
Accession No.  
P63165

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