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Rat IL-17AF

Recombinant Active Protein
Cat. No. 
600382
Unit 
0.025 mg
Price $250.00

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7985 Dunbrook Rd., Ste A
San Diego, CA 92126, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 
Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17RA receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Rat IL-17AF is produced in E.coli. Recombinant rat IL-17AF is a non-glycosylated, disulfide-linked heterodimer, containing one IL-17A subunit and one IL-17F subunit. The dimer has a total of 269 amino acids, with total molecular weight of 30.7 kDa.