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ABL1 (7B11) Antibody

Mouse Monoclonal Antibody
Cat. No. 
252799
Unit 
0.1 ml
Price $374.00

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Abbiotec

350 W. 9th Ave., Ste 107
Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252
Email: info@abbiotec.com
Description 

c-ABL (Proto-oncogene c-Abl) is a protein kinase that regulates key processes linked to cell growth and survival. c-ABL regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. C-ABL localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. c-ABL regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. A chromosomal aberration involving c-ABL1 is a cause of chronic myeloid leukemia.