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ACTR-IIB Antibody

Rabbit Polyclonal Antibody
Cat. No. 
0.1 mg
Price $365.00


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Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
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Activin receptor type-2B (ACTR-IIB), upon ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in ACTR-IIB are the cause of visceral heterotaxy autosomal type 4 (HTX4), a form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. HTX4 results in an abnormal arrangement of visceral organs and a wide variety of congenital defects.