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SOCS-3 Antibody

Rabbit Polyclonal Antibody

Cat. No.

250863

Unit

0.1 mg

Price $307.00

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Order directly from

Abbiotec

938 S. Andreasen Dr., Ste I
Escondido, CA 92029, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453

Fax: 1 858 586 6252

Email: info@abbiotec.com

Website: http://www.abbiotec.com

Description

Suppressor of cytokine signaling (SOCS) family proteins are involved in a negative feedback system that regulates cytokine signal transduction. SOCS-3 is involved in negative regulation of cytokines through the JAK/STAT signaling pathway by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL-12, GCSF and leptin receptors. Genetic variation in the promoter region of SOCS-3 is associated with susceptibility to atopic dermatitis 4 (eczema).

Spec Container

Datasheet

Data Left

Isotype

Rabbit Ig

Applications

IHC

Species Reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Alternate Names

Suppressor of cytokine signaling 3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3; SOCS3; CIS3; SSI3

Data Right

Accession No.

O14543

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SOCS-3.

Application Notes

E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Images

SOCS-3 staining in mouse hippocampus. Paraffin-embedded mouse hippocampus is stained with SOCS-3 Antibody (Cat. No. 250863) used at 1:200 dilution.

Citations

Product Citations

[1] Van den Brand B. et al. 2013. Arthritis Rheum. 65(3): 671-680. PMID# 23203851 [2] Van de Loo F et al. 2012. Arthritis Rheum. 64(10): 3313-3323. PMID# 22576756