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ADAM-TS7 Peptide

Synthetic Peptide
Blocking Peptide
Cat. No. 
0.1 mg
Price $88.00


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Escondido, CA 92025, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
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A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS7) is a metalloprotease that degrades COMP. ADAM-TS7 is up-regulated in articular cartilage and synovium from arthritis patients. The spacer domain and the thrombospondin type-1 domain are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.