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Thrombin Receptor Agonist Peptide

Synthetic Peptide
Cat. No. 
1 mg
Price $141.00


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938 S. Andreasen Dr., Ste I
Escondido, CA 92029, USA

Phone: 1 858 586 0500 x100,
1 800 854 7453
Fax: 1 858 586 6252

Thrombin signaling of platelets is mediated by a G protein-coupled protease-activated receptor (PAR). The PAR is activated after thrombin binding and subsequent cleavage of the amino terminal end of the receptor. This new amino terminus acts as a tethered ligand and binds intramolecularly to the body of the PAR, resulting in a transmembrane signal. Synthetic thrombin receptor agonist peptides (TRAP) of 6 residues (SFLLRN) and 14 residues (SFLLRNPNDKYEPF), respectively corresponding to aa42-47 and aa42-55 of the human thrombin receptor were found to be as effective as thrombin for Ca2+ mobilization. It was also shown that these peptides are far less active on pig and guinea pig platelets, whereas completely inactive on rat and rabbit platelets.