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Human PAI-1

Recombinant Protein
Cat. No. 
0.01 mg
Price $250.00


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Escondido, CA 92029, USA

Phone: 1 858 586 0500 x100,
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Plasminogen Activator Inhibitor 1 (PAI-1) is a serine protease inhibitor which can exist either in an active inhibitory conformation or in an inactive or latent conformation. PAI-1 is produced mainly by the endothelium but is also secreted by other tissue types including adipose tissue. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, therefore inhibiting fibrinolysis. Increased levels of PAI-1 have been linked with various conditions including cardiovascular disease, thrombosis, insulin resistance and obesity. Recombinant PAI-1 comprises a 379 amino acid fragment (24-402) corresponding to the mature PAI-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag.